A multicenter phase III study using HLA-unmatched allogeneic placenta-derived stromal cells (PLX-PAD) for the treatment of severe critical limb ischemia accompanied by mechanistic studies
Chasen Cottle, Amanda Paige Porter, Ariel Lipat , Caitlin Turner-Lyles, Jimmy Nguyen, Guido Moll, Raghavan Chinnadurai.
Impact of Cryopreservation and Freeze-Thawing on Therapeutic Properties of Mesenchymal Stromal/Stem Cells and Other Common Cellular Therapeutics.
Curr. Stem Cell Rep. 2022. doi: 10.1007/s40778-022-00212-1.
![]() |
open it on the web |
Vivian Capilla-González, Vicente Herranz-Pérez, Rachel Sarabia-Estrada, Nadir Kadri and Guido Moll.
Mesenchymal Stromal Cell Therapy for Regenerative Medicine.
Front. Cell. Neurosci. 2022. doi: 10.3389/fncel.2022.932281.
![]() |
open it on the web |
Olle Ringden, Guido Moll, Britt Gustavsson, Behnam Sadeghi.
Mesenchymal Stromal Cells for Enhancing Hematopoietic Engraftment and Treatment of Graft-versus-Host Disease, Hemorrhages and Acute Respiratory Distress Syndrome.
Frontiers in Immunology. 2022. doi: 10.3389/fimmu.2022.839844.
![]() |
open it on the web |
Jayeeta Giri and Guido Moll.
MSCs in Space: Mesenchymal Stromal Cell Therapeutics as Enabling Technology for Long-Distance Manned Space Travel.
Current Stem Cell Reports. 2022 doi: 10.1007/s40778-022-00207-y.
![]() |
open it on the web |
Guido Moll, James A. Ankrum, Scott D. Olson, Jan A. Nolta.
Improved MSC Minimal Criteria to Maximize Patient Safety: A Call to Embrace Tissue Factor and Hemocompatibility Assessment of MSC Products.
Stem Cells Translational Medicine 2022 doi: 10.1093/stcltm/szab005.
![]() |
open it on the web |
Rusan Catar and Guido Moll et al.
Angiogenic Role of Mesothelium-Derived Chemokine CXCL1 during Unfavourable Peritoneal Tissue Remodelling in Patients Receiving Peritoneal Dialysis as Renal Replacement Therapy.
Frontiers in Immunology. 2022 doi: 10.3389/fimmu.2022.821681.
![]() |
open it on the web |
Rusan Catar and Guido Moll et al.
Expanded Hemodialysis Therapy Ameliorates Uremia-Induced Systemic Microinflammation and Endothelial Dysfunction by Modulating VEGF, TNF-α and AP-1 Signaling.
Frontiers in Immunology. 2022 doi: 10.3389/fimmu.2022.821681.
![]() |
open it on the web |
Fausto Gueths Gomes, André Cronemberger Andrade, Martin Wolf, Sarah Hochmann, Linda Krisch, Nicole Maeding, Christof Regl, Rodolphe Poupardin, Patricia Ebner-Peking, Christian G Huber, Nicole Meisner-Kober, Katharina Schallmoser, Dirk Strunk.
Synergy of human platelet-derived extracellular vesicles with secretome proteins promotes regenerative functions.
Biomedicines. 2022, 10, 238. doi: 10.3390/biomedicines10020238.
![]() |
open it on the web |
Gady Goldsobel, Christoph von Herrath, Stephan Schlickeiser, Nicola Brindle, Frauke Stähler, Petra Reinke, Zami Aberman, Racheli Ofir, Gabriella Dessole, Stefano Benvenuti, Nuno M. Neves, Rui L. Reis, Guido Moll, and Hans-Dieter Volk.
RESTORE Survey on the Public Perception of Advanced Therapies and ATMPs in Europe. Why the European Union Should Invest More!
Frontiers in Medicine. 2021 doi: 10.3389/fmed.2021.739987.
![]() |
open it on the web |
Sandra Laner-Plamberger, Michaela Oeller, Eva Rohde, Katharina Schallmoser, Dirk Strunk.
Heparin and Derivatives for Advanced Cell Therapies.
Int. J. Mol. Sci. 2021, 22, 12041. doi: 10.3390/ijms222112041.
![]() |
open it on the web |
Heide-Marie Binder, Nicole Maeding, Martin Wolf, André Cronemberger Andrade, Balazs Vari, Linda Krisch, Fausto Gueths Gomes, Constantin Blöchl, Katharina Muigg, Rodolphe Pourpadin, Thomas Heuser, Astrid Obermayer, Patricia Peking, Christian G Huber, Katharina Schallmoser, Dirk Strunk.
Scalable Enrichment of Immunomodulatory Human Acute Myeloid Leukemia Cell Line-Derived Extracellular Vesicles.
Cells. 2021, 10, 3321. doi: 10.3390/cells10123321.
![]() |
open it on the web |
Michaela Oeller, Sandra Laner-Plamberger, Linda Krisch, Eva Rohde, Dirk Strunk, Katharina Schallmoser.
Human Platelet Lysate for Good Manufacturing Practice-Compliant Cell Production.
Int. J. Mol. Sci. 2021, 22, 5178, doi: 10.3390/ijms22105178.
![]() |
open it on the web |
Rusan Catar, Guido Moll, Isa Hosp, Michel Simon, Christian Luecht, Hongfan Zhao, Dashan Wu, Lei Chen, Julian Kamhieh-Milz, Katarzyna Korybalska, Daniel Zickler, Janusz Witowski.
Transcriptional Regulation of Thrombin-Induced Endothelial VEGF Induction and Proangiogenic Response.
Cells. 2021 Apr 15;10(4):910. doi: 10.3390/cells10040910.
![]() |
open it on the web |
Norman Drzeniek, Andrea Mazzocchi, StephanSchlickeiser, Steven Forsythe, Guido Moll, Sven Geissler, Petra Reinke, Manfred Gossen, Vijay Gorantla, Hans-Dieter Volk, Shay Soker.
Bio-instructive hydrogel expands the paracrine potency of mesenchymal stem cells.
Biofabrication. 2021 Jul 8;13(4). doi: 10.1088/1758-5090/ac0a32.
![]() |
open it on the web |
André Cronemberger Andrade, Martin Wolf, Heide-Marie Binder, Fausto Gueths Gomes, Felix Manstein, Patricia Ebner-Peking, Rodolphe Poupardin, Robert Zweigerdt, Katharina Schallmoser, Dirk Strunk.
Hypoxic Conditions Promote the Angiogenic Potential of Human Induced Pluripotent Stem Cell-Derived Extracellular Vesicles.
International Journal of Molecular Sciences. 2021, 22(8), 3890. doi: 10.3390/ijms22083890.
![]() |
open it on the web |
Rodolphe Poupardin, Martin Wolf, Dirk Strunk.
Adherence to minimal experimental requirements for defining extracellular vesicles and their functions.
Advanced Drug Delivery Reviews. 2021 Sep;176:113872. doi: 10.1016/j.addr.2021.113872. Epub 2021 Jul 17.
![]() |
open it on the web |
Patricia Ebner-Peking, Linda Krisch, Martin Wolf, Anna Hoog, Sarah Hoch-mann, Balázs Vári, Katharina Muigg, Rodolphe Poupardin, Cornelia Scharler, Sabine Schmidhuber, Elis-abeth Russe, Harald Stachelscheid, Achim Schneeberger, Katharina Schallmoser, Dirk Strunk.
Self-assembly of differentiated progenitor cells facilitates spheroid human skin organoid formation and planar skin regeneration.
Theranostics. 2021 Jul 25;11(17):8430-8447. doi: 10.7150/thno.59661. eCollection 2021.
![]() |
open it on the web |
Guido Moll, Norman Drzeniek, Julian Kamhieh-Milz,Sven Geissler and Petra Reinke.
MSC Therapies for COVID-19: Importance of Patient Coagulopathy, Thromboprophylaxis, Cell Product Quality and Mode of Delivery for Treatment Safety and Efficacy.
Front. Immunology. 2020, 11, 1091, DOI: 10.3389/fimmu.2020.01091
![]() |
open it on the web |
Guido Moll, Norman Drzeniek, Julian Kamhieh-Milz,Sven Geissler and Petra Reinke.
Editorial comment: variables affecting the presence of mesenchymal stromal cells in the peripheral blood and their relationship with apheresis product.
British Journal of Haematology. 2020
![]() |
download the publication |
Guido Moll, Martin J. Hoogduijn and James A. Ankrum.
Editorial: Safety, Efficacy and Mechanisms of Action of Mesenchymal Stem Cell Therapies.
Frontiers in Immunology. 2020, 11 Art 243
![]() |
download the publication |
Moll G, Ankrum JA, Kamhieh-Milz J, Bieback K, Ringdén O, Volk HD, Geissler S*, Reinke P* (*shared senior).
Intravascular Mesenchymal Stromal/Stem Cell Therapy Product Diversification: Time for New Clinical Guidelines.
Trends Mol Med. 2019 doi: 10.1016/j.molmed.2018.12.006.
![]() |
open it on the web |
Behnam Sadeghi, Gianluca Moretti , Fabian Arnberg, Erik Samén, Bita Kohein, Rusan Catar, Julian Kamhieh-Milz , Sven Geissler , Guido Moll, Staffan Holmin,and Olle Ringdén.
Preclinical Toxicity Evaluation of Clinical Grade Placenta-Derived Decidua Stromal Cells.
Frontiers in Immunology. 2019, 10 Art 2685
![]() |
download the publication |
Anastazja Andrzejewska, Rusan Catar, Janosch Schoon, Taimoor Hasan Qazi, Frauke Andrea Sass, Dorit Jacobi, Antje Blankenstein, Simon Reinke, David Krüger, Mathias Streitz, Stephan Schlickeiser, Sarina Richter, Naima Souidi, Christien Beez, Julian Kamhieh-Milz, Ulrike Krüger, Tomasz Zemojtel, Karsten Jürchot, Dirk Strunk, Petra Reinke, Georg Duda, Guido Moll* and Sven Geissler.
Multi-Parameter Analysis of Biobanked Human Bone Marrow Stromal Cells Shows Little Influence for Donor Age and Mild Comorbidities on Phenotypic and Functional Properties.
Frontiers in Immunology. 2019, 10 Art 2474
![]() |
download the publication |
Lars Norgren Norbert Weiss, Sigrid Nikol, Robert J. Hinchliffe , John C. Lantis , Manesh R. Patel , Holger Reinecke ,Racheli Ofir, Yael Rosen, Dan Peres, Zami Aberman.
PLX-PAD Cell Treatment of Critical Limb Ischaemia: Rationale and Design of the PACE Trial.
Eur J Vasc Endovasc Surg. 2019 Jan 24 in press
![]() |
open it on the web |
Chotima Böttcher, Stephan Schlickeiser, Marjolein A. M. Sneeboer, Desiree Kunkel, Anniki Knop, Evdokia Paza, Pawel Fidzinski, Larissa Kraus, Gijsje J. L. Snijders, René S Kahn, Axel R Schulz, Henrik E Mei, NBB-Psy, Elly M. Hol, Britta Siegmund, Rainer Glauben, Eike J Spruth, Lot D de Witte & Josef Priller.
Human microglia regional heterogeneity and phenotypes determined by multiplexed single-cell mass cytometry.
Development and usage of a statistical analysis pipeline for high-dimensional mass cytometry data
Journal:
Nature Neuroscience. 22, pages78–90 (2019)
![]() |
open it on the web |
Maura Farinacci, Thomas Krahn, Wilfried Dinh Hans-Dieter Volk, Hans-Dirk Düngen, Josephine Wagner | Timo Konen, Oliver von Ahsen.
Circulating endothelial cells as biomarker for cardiovascular diseases.
Res Pract Thromb Haemost. 2018; 49-58, DOI: 10.1002/rth2.12158
![]() |
open it on the web |